What is the recommended dosage of Epinephrine for treating an allergic reaction/anaphylaxis when administered intramuscularly?

The recommended dosage of Epinephrine for treating severe allergic reactions or anaphylaxis in adults is typically 0.3 to 0.5 mg when administered intramuscularly. The choice of 0.3mg is often the initial recommended dose for adults in many guidelines, including those established by the American Heart Association and other relevant health organizations. This dosage is considered effective for rapidly counteracting the severe symptoms associated with anaphylaxis, such as airway swelling, breathing difficulties, and decreased blood pressure.

When considering a pediatric dose, it is often recommended as 0.01 mg/kg, up to a maximum of 0.3mg, which aligns with the rationale for choosing 0.3mg for adult use as a standard starting point. This dosing strategy ensures a balance between efficacy and safety in managing the acute symptoms of anaphylaxis while minimizing potential side effects.